Technical notes: HBV-related death rate

Technical notes: HBV-related death rate

Description

Estimated HBV-related death rate per 100,000 population for all ages, both sexes in 2017.  

HBV-related deaths include deaths due to acute HBV, cirrhosis and other chronic liver diseases attributable to HBV, and liver cancer attributable to HBV.

Sources

Modelled

All country data dashboards show the estimated HBV death rate from the Institute of Health Metrics and Evaluation.

Institute for Health Metrics and Evaluation. Global Burden of Disease Project, 2017. 

This data can be accessed at: http://ghdx.healthdata.org/gbd-results-tool

Select countries may have other reported death rates that are sourced from published national data sources. In the case of two death rates, the one from national data sources can be identified by information in the indicator title on the dashboard. For example, on the United States page, the HBV-death rate title reads:” per 100,000 HBV-related deaths 2016, National Vital Registry, US CDC.” These death rates are generally based on death records or other national surveillance systems.

This national data was either provided by local program managers or was identified by CGHE staff through a web-based search. CGHE would be happy to add nationally sourced death rates for additional countries. Please contact: to share any data.

National data sources include

Centers for Disease Control. Viral Hepatitis Surveillance United States, 2016. Available at : https://www.cdc.gov/hepatitis/statistics/2016surveillance/pdfs/2016HepSurveillanceRpt.pdf

These country resources can be accessed on their respective country pages as well.

Comparing modelled and national HBV-related death rates

In some cases, the death rates shown from IHME and the one published by the country may be different.These differences could be due to differences in methodology.

The IHME death-rate is an estimated value that incorporates methods to adjust for incomplete or missing vital registration (VR) and verbal autopsy (VA) data, general heterogeneity in data completeness and quality, and the redistribution of unclassifiable death codes. More information on this approach is available in the annex of the GBD 2017 mortality estimation paper: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32203-7/fulltext (GBD Cause of Death 2017 Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017).

Country-reported data may follow other guidelines. For example, the US-reported number adjusted for under-ascertainment and under-reporting based on methods described in this paper: https://www.ncbi.nlm.nih.gov/pubmed/24432918 (Klevens RM et al. Estimating acute viral hepatitis infections from nationally reported cases. Am J Public Health. 2014 Mar;104(3):482-7).

For population denominators, IHME also used a set of modelling tools, including the GBD Cause of Death Ensemble model (CODEm), to generate cause fractions and cause-specific death rates for each location, year, age, and sex.  GBD 2017 independently estimated population size and fertility rate for all locations.  The nationally reported death rate may have a more country-specific approach. The death-rate for the US was computed by applying age-specific death rates to the U.S. standard population (relative age distribution of year 2000 (census) with population projections) (Centers for Disease Control. Viral Hepatitis Surveillance United States, 2016. Available at : https://www.cdc.gov/hepatitis/statistics/2016surveillance/pdfs/2016HepSurveillanceRpt.pdf